Marina Konopleva Selected Research

bcr-abl Fusion Proteins

1/2016	Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells.
10/2015	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells.
9/2009	Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.
1/2008	CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells.
10/2006	Regulation and targeting of Eg5, a mitotic motor protein in blast crisis CML: overcoming imatinib resistance.

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Marina Konopleva Research Topics

Disease

193	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 05/2024 - 01/2002
124	Neoplasms (Cancer) 05/2024 - 07/2002
111	Leukemia 04/2024 - 07/2002
61	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2024 - 03/2004
38	Philadelphia Chromosome 04/2024 - 10/2006
29	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 03/2024 - 09/2006
27	Hematologic Neoplasms (Hematological Malignancy) 04/2024 - 01/2002
22	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 01/2008
17	Hypoxia (Hypoxemia) 01/2023 - 08/2009
15	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 10/2023 - 10/2004
14	Lymphoma (Lymphomas) 01/2023 - 10/2004
12	Infections 11/2023 - 03/2004
12	Acute Promyelocytic Leukemia 01/2022 - 03/2004
11	Blast Crisis (Blast Phase) 01/2023 - 10/2006
10	Exanthema (Rash) 11/2023 - 07/2015
10	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2023 - 03/2014
9	Residual Neoplasm 12/2022 - 01/2017
7	Graft vs Host Disease (Graft-Versus-Host Disease) 02/2024 - 05/2007
7	Breast Neoplasms (Breast Cancer) 01/2013 - 03/2003
6	B-Cell Lymphoma (Lymphoma, B Cell) 11/2023 - 06/2007
5	Nausea 11/2023 - 07/2015
5	Hypertension (High Blood Pressure) 01/2023 - 01/2011
5	Thrombocytopenia (Thrombopenia) 01/2022 - 01/2018
5	Chromosome Aberrations (Chromosome Abnormalities) 01/2022 - 03/2017
5	Disease Progression 01/2021 - 05/2017
5	Pathologic Complete Response 07/2020 - 05/2015
4	Inflammation (Inflammations) 02/2024 - 03/2006

Drug/Important Bio-Agent (IBA)

67	venetoclaxIBA 01/2024 - 03/2014
50	Proteins (Proteins, Gene)FDA Link 03/2024 - 08/2004
27	Tyrosine Kinase InhibitorsIBA 10/2023 - 02/2010
26	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2023 - 03/2004
22	Azacitidine (5 Azacytidine)FDA Link 01/2024 - 06/2013
18	TriterpenesIBA 06/2012 - 01/2002
16	Phosphotransferases (Kinase)IBA 01/2023 - 04/2006
15	bardoxoloneIBA 12/2010 - 01/2002
12	ponatinibIBA 04/2024 - 09/2014
12	Sorafenib (BAY 43-9006)FDA Link 11/2023 - 02/2008
12	bardoxolone methylIBA 08/2014 - 01/2002
10	tagraxofuspIBA 04/2024 - 07/2014
10	AcidsIBA 11/2007 - 09/2003
9	Cyclophosphamide (Cytoxan)FDA LinkGeneric 02/2024 - 03/2004
9	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 11/2023 - 11/2013
9	Dasatinib (BMS 354825)FDA Link 10/2023 - 01/2017
9	Decitabine FDA Link 08/2023 - 09/2012
9	Oxygen (Dioxygen)IBA 01/2023 - 01/2010
9	fms-Like Tyrosine Kinase 3IBA 01/2023 - 04/2006
9	blinatumomabIBA 01/2023 - 12/2017
8	Biomarkers (Surrogate Marker)IBA 01/2023 - 07/2012
8	fludarabineIBA 12/2021 - 08/2006
8	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 03/2003
8	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019 - 05/2002
7	ABT-737IBA 09/2021 - 11/2006
7	Vincristine (Oncovin)FDA LinkGeneric 01/2021 - 03/2004
7	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 01/2010
7	Imatinib Mesylate (Gleevec)FDA Link 01/2016 - 10/2006
6	GlutaminaseIBA 02/2023 - 11/2016
6	Glutamine (L-Glutamine)FDA Link 02/2023 - 11/2013
6	ibrutinibIBA 01/2023 - 05/2015
6	Inotuzumab OzogamicinIBA 01/2022 - 01/2018
6	Clofarabine (Clolar)FDA Link 01/2021 - 09/2012
6	LigandsIBA 11/2020 - 07/2002
6	ProdrugsIBA 05/2017 - 01/2011
6	TOR Serine-Threonine KinasesIBA 11/2015 - 09/2006
6	EstersIBA 12/2010 - 01/2002
6	PPAR gammaIBA 06/2010 - 07/2002
5	CytokinesIBA 05/2024 - 11/2005
5	Asparaginase (Elspar)FDA Link 04/2024 - 11/2013
5	DNA (Deoxyribonucleic Acid)IBA 02/2024 - 12/2012
5	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 01/2024 - 12/2011
5	Immune Checkpoint InhibitorsIBA 06/2023 - 01/2021
5	IACS-010759IBA 01/2023 - 01/2018
5	Transaminases (Aminotransferases)IBA 10/2022 - 11/2017
5	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2022 - 02/2006
5	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021 - 03/2004
5	Protein Isoforms (Isoforms)IBA 01/2021 - 03/2003
5	nutlin 3IBA 01/2017 - 08/2006
5	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 03/2004
5	bcr-abl Fusion ProteinsIBA 01/2016 - 10/2006
4	Monoclonal AntibodiesIBA 12/2023 - 03/2014
4	BilirubinIBA 11/2023 - 09/2018
4	navitoclaxIBA 11/2023 - 07/2015
4	NivolumabIBA 01/2023 - 01/2019
4	Alanine Transaminase (SGPT)IBA 01/2023 - 11/2015
4	Agammaglobulinaemia Tyrosine KinaseIBA 01/2023 - 05/2015
4	NucleophosminIBA 01/2023 - 12/2013
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 11/2022 - 04/2014
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2022 - 04/2005
4	CreatinineIBA 01/2022 - 10/2011
4	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 11/2020 - 06/2009
4	plerixafor FDA Link 11/2020 - 01/2013
4	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2019 - 12/2007
4	Arsenic Trioxide (Trisenox)FDA Link 01/2019 - 05/2015
4	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2010

Therapy/Procedure

132	Therapeutics 05/2024 - 09/2003
76	Drug Therapy (Chemotherapy) 01/2024 - 11/2004
14	Stem Cell Transplantation 01/2023 - 07/2007
8	Hematopoietic Stem Cell Transplantation 02/2024 - 05/2007
6	Induction Chemotherapy 09/2019 - 03/2004
5	Immunotherapy 10/2023 - 01/2021
4	Salvage Therapy 01/2021 - 09/2015